This area develops theoretical foundations, models, and methods for adaptation and self-awareness of composite IoBT assets (assembled together using the discovery, recruitment, synthesis, and goal-driven network optimization mechanisms developed under “Assured Synthesis”). In biological systems, reflex theory states that complex behavior can be attained (and thus explained) through the combined action of individual reflexes that have been chained together. The goal of this research area is to develop a parallel theory for IoBTs that offers foundations, models, and methods for adaptive, autonomic, and (more generally) self-aware behavior in the face of distribution, scale, dynamics, heterogeneity, resource constraints, and presence of adversaries.